The secrets of life lie in the molecular flexibility.

Welcome to Prof. Mariusz Jaremko's research group, the

Flexible Systems Lab!

Our research group works mainly on metabolites which are important for human health, and our current main focus in this discipline is oriented towards food, food safety, food quality, and food fraud by utilizing state-of-the-art instrumentation in metabolomics studies. We are also working on aggregation of amylin, a biological peptide that is connected tightly with diabetes II, a disease that is closely related to unhealthy diets. So, food science and the consequences of the food we eat are one of the main areas which the group Flexible Systems investigates. We are also working to develop methods and pulse programs in Nuclear Magnetic Resonance (NMR) that allow us to uncover obscured metabolites and to detect them at lower concentrations, in order to understand metabolic pathways better. 


Why the name Flexible Systems?

It's simple; because metabolites, as well as amylin and its analogues, are very flexible systems i.e. amylin does not have a defined 3D structure, and in the case of the small molecules and metabolites we study, while they do have defined structures, they often exhibit very high levels of dynamic flexibility due to their size.

Latest Publications

Chapter 1: Theory and Applications of NMR Spectroscopy in Biomolecular Structures and Dynamics of Proteins
Book Chapter Year: 2022 DOI:https://doi.org/10.1039/9781839165702-00001
Authors: Kousik Chandra, Abdul-Hamid Emwas, Samah Al-Harthi, Zeyad A. Al-Talla, Dina Hajjar, Arwa A. Makki, Ghada Khouqeer, Mariusz Jaremko
Thymosin β4 Is an Endogenous Iron Chelator and Molecular Switcher of Ferroptosis
Original Article Year: 2022 DOI:https://doi.org/10.3390/ijms23010551
Authors: Joanna Izabela Lachowicz, Giusi Pichiri, Marco Piludu, Sara Fais, Germano Orru, Terenzio Congiu, Monica Piras, Gavino Faa, Daniela Fanni, Gabriele Dalla Torre, Xabier Lopez, Kousik Chandra, Kacper Szczepski, Lukasz Jaremko, Mitra Ghosh, Abdul-Hamid Emwas, Massimo Castagnola, Mariusz Jaremko, Ewald Hannappel, Pierpaolo Coni
Extraction, Characterization, and Anticoagulant Activity of a Sulfated Polysaccharide from Bursatella leachii Viscera
Original Article Year: 2020 DOI:https://doi.org/10.1021/acsomega.0c01724
Authors: Manel Dhahri, Salim Sioud, Rihab Dridi, Mohsen Hassine, Naceur A. Boughattas, Fatimah Almulhim, Zeyad A. Al-Talla, Mariusz Jaremko, Abdul-Hamid Emwas