The secrets of life lie in the molecular flexibility.

Welcome to Prof. Mariusz Jaremko's research group, the

Flexible Systems Lab!

Our research group works mainly on metabolites which are important for human health, and our current main focus in this discipline is oriented towards food, food safety, food quality, and food fraud by utilizing state-of-the-art instrumentation in metabolomics studies. We are also working on aggregation of amylin, a biological peptide that is connected tightly with diabetes II, a disease that is closely related to unhealthy diets. So, food science and the consequences of the food we eat are one of the main areas which the group Flexible Systems investigates. We are also working to develop methods and pulse programs in Nuclear Magnetic Resonance (NMR) that allow us to uncover obscured metabolites and to detect them at lower concentrations, in order to understand metabolic pathways better. 


Why the name Flexible Systems?

It's simple; because metabolites, as well as amylin and its analogues, are very flexible systems i.e. amylin does not have a defined 3D structure, and in the case of the small molecules and metabolites we study, while they do have defined structures, they often exhibit very high levels of dynamic flexibility due to their size.

Latest Publications

The robust NMR toolbox for metabolomics
Review Article Year: 2021 DOI:https://doi.org/10.1039/D1MO00118C
Authors: Kousik Chandra, Samah Al-Harthi, Fatimah Almulhim, Abdul-Hamid Emwas, Lukasz Jaremko, Mariusz Jaremko
You Are What You Eat: Application of Metabolomics Approaches to Advance Nutrition Research
Review Article Year: 2021 DOI:https://doi.org/10.3390/foods10061249
Authors: Abdul-Hamid Emwas, Nahla Al-Rifai, Kacper Szczepski, Shuruq Alsuhaymi, Saleh Rayyan, Hanan Almahasheer, Mariusz Jaremko, Lorraine Brennan, Joanna Izabela Lachowicz
Fluxomics - New Metabolomics Approaches to Monitor Metabolic Pathways
Review Article Year: 2022 DOI:https://doi.org/10.3389/fphar.2022.805782
Authors: Abdul-Hamid Emwas, Kacper Szczepski, Inas Al-Younis, Joanna Izabela Lachowicz, Mariusz Jaremko