The secrets of life lie in the molecular flexibility.

Welcome to Prof. Mariusz Jaremko's research group, the

Flexible Systems Lab!

Our research group works mainly on metabolites which are important for human health, and our current main focus in this discipline is oriented towards food, food safety, food quality, and food fraud by utilizing state-of-the-art instrumentation in metabolomics studies. We are also working on aggregation of amylin, a biological peptide that is connected tightly with diabetes II, a disease that is closely related to unhealthy diets. So, food science and the consequences of the food we eat are one of the main areas which the group Flexible Systems investigates. We are also working to develop methods and pulse programs in Nuclear Magnetic Resonance (NMR) that allow us to uncover obscured metabolites and to detect them at lower concentrations, in order to understand metabolic pathways better. 


Why the name Flexible Systems?

It's simple; because metabolites, as well as amylin and its analogues, are very flexible systems i.e. amylin does not have a defined 3D structure, and in the case of the small molecules and metabolites we study, while they do have defined structures, they often exhibit very high levels of dynamic flexibility due to their size.

Latest Publications

Using NMR spectroscopy to investigate the role played by copper in prion diseases
Original Article Year: 2020 DOI:http://dx.doi.org/10.1007/s10072-020-04321-9
Authors: Rawiah Alsiary, Mawadda Alghrably, Abdelhamid Saoudi, Suliman Al-Ghamdi, Lukasz Jaremko, Mariusz Jaremko, Abdul-Hamid Emwas
Pharmacometabolomics: A New Horizon in Personalized Medicine
Book Chapter Year: 2020 DOI:10.5772/intechopen.98911
Authors: Abdul-Hamid Emwas, Kacper Szczepski, Ryan T. McKay, Hiba Asfour, Chung-ke Chang, Joanna Izabela Lachowicz, Mariusz Jaremko
New Advances in Fast Methods of 2D NMR Experiments
Book Chapter Year: 2019 DOI:http://dx.doi.org/10.5772/intechopen.90263
Authors: Abdul-Hamid Emwas, Mawadda Alghrably, Samah Al-Harthi, Benjamin Gabriel Poulson, Kacper Szczepski, Kousik Chandra, Mariusz Jaremko