The secrets of life lie in the molecular flexibility.

Welcome to Prof. Mariusz Jaremko's research group, the

Flexible Systems Lab!

Our research group works mainly on metabolites which are important for human health, and our current main focus in this discipline is oriented towards food, food safety, food quality, and food fraud by utilizing state-of-the-art instrumentation in metabolomics studies. We are also working on aggregation of amylin, a biological peptide that is connected tightly with diabetes II, a disease that is closely related to unhealthy diets. So, food science and the consequences of the food we eat are one of the main areas which the group Flexible Systems investigates. We are also working to develop methods and pulse programs in Nuclear Magnetic Resonance (NMR) that allow us to uncover obscured metabolites and to detect them at lower concentrations, in order to understand metabolic pathways better. 


Why the name Flexible Systems?

It's simple; because metabolites, as well as amylin and its analogues, are very flexible systems i.e. amylin does not have a defined 3D structure, and in the case of the small molecules and metabolites we study, while they do have defined structures, they often exhibit very high levels of dynamic flexibility due to their size.

Latest Publications

Metabolomic Study on Tridacna maxima Giant Clams Reveals Metabolic Fingerprint of Environmental Pollutants
Original Article Year: 2022 DOI:https://doi.org/10.3389/fmars.2022.813404
Authors: Fatimah Almulhim, Susann Rossbach, Abdul-Hamid Emwas, Najeh M. Kharbatia, Lukasz Jaremko, Mariusz Jaremko, Carlos Duarte
Chapter 5 - Metabolic biomarkers in cancer
Book Chapter Year: 2023 DOI:https://doi.org/10.1016/B978-0-323-99924-3.00005-4
Authors: Kacper Szczepski, Inas Al-Younis, Manel Dhahri, Joanna Izabela Lachowicz, Zeyad A. Al-Talla, Hanan Almahasheer, Noura Alasmael, Mahbuba Rahman, Abdul-Hamid Emwas, Lukasz Jaremko, Mariusz Jaremko
NMR-based metabolomics with enhanced sensitivity
Original Article Year: 2021 DOI:https://doi.org/10.1039/D1RA01103K
Authors: Kousik Chandra, Samah Al-Harthi, Sujeesh Sukumaran, Fatimah Almulhim, Abdul-Hamid Emwas, Hanudatta S. Atreya, Lukasz Jaremko, Mariusz Jaremko