The secrets of life lie in the molecular flexibility.

Welcome to Prof. Mariusz Jaremko's research group, the

Flexible Systems Lab!

Our research group works mainly on metabolites which are important for human health, and our current main focus in this discipline is oriented towards food, food safety, food quality, and food fraud by utilizing state-of-the-art instrumentation in metabolomics studies. We are also working on aggregation of amylin, a biological peptide that is connected tightly with diabetes II, a disease that is closely related to unhealthy diets. So, food science and the consequences of the food we eat are one of the main areas which the group Flexible Systems investigates. We are also working to develop methods and pulse programs in Nuclear Magnetic Resonance (NMR) that allow us to uncover obscured metabolites and to detect them at lower concentrations, in order to understand metabolic pathways better. 


Why the name Flexible Systems?

It's simple; because metabolites, as well as amylin and its analogues, are very flexible systems i.e. amylin does not have a defined 3D structure, and in the case of the small molecules and metabolites we study, while they do have defined structures, they often exhibit very high levels of dynamic flexibility due to their size.

Latest Publications

NMR Spectroscopy for Metabolomics Research
Review Article Year: 2019 DOI:https://doi.org/10.3390/metabo9070123
Authors: Abdul-Hamid Emwas, Raja Roy, Ryan T. McKay, Leonardo Tenori, Edoardo Saccenti, G. A. Nagana Gowda, Daniel Raftery, Fatimah Alahmari, Lukasz Jaremko, Mariusz Jaremko, David S. Wishart
Untargeted Metabolomic Profiling and Antioxidant Capacities of Different Solvent Crude Extracts of Ephedra foeminea
Original Article Year: 2022 DOI:https://doi.org/10.3390/metabo12050451
Authors: Ruba Al-Nemi, Arwa A. Makki, Khaled Sawalha, Dina Hajjar, Mariusz Jaremko
Compound-Specific 1D 1H NMR Pulse Sequence Selection for Metabolomics Analyses
Original Article Year: 2023 DOI:10.1021/acsomega.3c01688
Authors: Upendra Singh, Shuruq Alsuhaymi, Ruba Al-Nemi, Abdul-Hamid Emwas, Mariusz Jaremko