The secrets of life lie in the molecular flexibility.

Welcome to Prof. Mariusz Jaremko's research group, the

Flexible Systems Lab!

Our research group works mainly on metabolites which are important for human health, and our current main focus in this discipline is oriented towards food, food safety, food quality, and food fraud by utilizing state-of-the-art instrumentation in metabolomics studies. We are also working on aggregation of amylin, a biological peptide that is connected tightly with diabetes II, a disease that is closely related to unhealthy diets. So, food science and the consequences of the food we eat are one of the main areas which the group Flexible Systems investigates. We are also working to develop methods and pulse programs in Nuclear Magnetic Resonance (NMR) that allow us to uncover obscured metabolites and to detect them at lower concentrations, in order to understand metabolic pathways better. 


Why the name Flexible Systems?

It's simple; because metabolites, as well as amylin and its analogues, are very flexible systems i.e. amylin does not have a defined 3D structure, and in the case of the small molecules and metabolites we study, while they do have defined structures, they often exhibit very high levels of dynamic flexibility due to their size.

Latest Publications

Alkaloids as potential antivirals. A comprehensive review
Review Article Year: 2023 DOI:https://doi.org/10.1007/s13659-022-00366-9
Authors: Shah Faisal, Syed Lal Badshah, Bibi Kubra, Abdul-Hamid Emwas, Mariusz Jaremko
  • Natural products
Extraction, Characterization, and Antioxidant Activity of Polysaccharides from Ajwa Seed and Flesh
Year: 2023 DOI:https://doi.org/10.3390/separations10020103
Authors: Manel Dhahri, Salim Sioud, Shuruq Alsuhaymi, Fatimah Almulhim, Ali Haneef, Abdelhamid Saoudi, Mariusz Jaremko, Abdul-Hamid Emwas
Natural Polysaccharides as Preventive and Therapeutic Horizon for Neurodegenerative Diseases
Review Article Year: 2022 DOI:http://dx.doi.org/10.3390/pharmaceutics14010001
Authors: Manel Dhahri, Mawadda Alghrably, Hamdoon A. Mohammed, Syed Lal Badshah, Noreen Noreen, Fouzi Mouffouk, Saleh Rayyan, Kamal A. Qureshi, Danish Mahmood, Joanna Izabela Lachowicz, Mariusz Jaremko, Abdul-Hamid Emwas