The secrets of life lie in the molecular flexibility.

Welcome to Prof. Mariusz Jaremko's research group, the

Flexible Systems Lab!

Our research group works mainly on metabolites which are important for human health, and our current main focus in this discipline is oriented towards food, food safety, food quality, and food fraud by utilizing state-of-the-art instrumentation in metabolomics studies. We are also working on aggregation of amylin, a biological peptide that is connected tightly with diabetes II, a disease that is closely related to unhealthy diets. So, food science and the consequences of the food we eat are one of the main areas which the group Flexible Systems investigates. We are also working to develop methods and pulse programs in Nuclear Magnetic Resonance (NMR) that allow us to uncover obscured metabolites and to detect them at lower concentrations, in order to understand metabolic pathways better. 


Why the name Flexible Systems?

It's simple; because metabolites, as well as amylin and its analogues, are very flexible systems i.e. amylin does not have a defined 3D structure, and in the case of the small molecules and metabolites we study, while they do have defined structures, they often exhibit very high levels of dynamic flexibility due to their size.

Latest Publications

Exploring the central region of amylin and its analogs aggregation: the influence of metal ions and residue substitutions
Original Article Year: 2024 DOI:https://doi.org/10.3389/fchem.2024.1419019
Authors: Mawadda Alghrably, Giulia Bennici, Gabriela Szczupaj, Noura Alasmael, Somayah Qutub, Batoul Maatouk, Kousik Chandra, Michal Nowakowski, Abdul-Hamid Emwas, Mariusz Jaremko
  • Aggregation
  • Amylin
Chapter 4 - A new frontier in cancer therapy: The intersection of cancer vaccines and metabolomics
Book Chapter Year: 2024 DOI:https://doi.org/10.1016/B978-0-443-15526-0.00009-3
Authors: Farah Ayman Sukareh, Ruba Al-Nemi, Peter Karagiannis, Hiba Asfour, Amita Verma, Mariusz Jaremko, Abdul-Hamid Emwas
  • Metabolomics
Untargeted metabolomics analysis of four date palm (Phoenix dactylifera L.) cultivars using MS and NMR
Original Article Year: 2023 DOI:https://doi.org/10.1007/s13659-023-00406-y
Authors: Shuruq Alsuhaymi, Upendra Singh, Inas Al-Younis, Najeh M. Kharbatia, Ali Haneef, Kousik Chandra, Manel Dhahri, Mohammed A. Assiri, Abdul-Hamid Emwas, Mariusz Jaremko
  • Natural products
  • Metabolomics