The secrets of life lie in the molecular flexibility.

Welcome to Prof. Mariusz Jaremko's research group, the

Flexible Systems Lab!

Our research group works mainly on metabolites which are important for human health, and our current main focus in this discipline is oriented towards food, food safety, food quality, and food fraud by utilizing state-of-the-art instrumentation in metabolomics studies. We are also working on aggregation of amylin, a biological peptide that is connected tightly with diabetes II, a disease that is closely related to unhealthy diets. So, food science and the consequences of the food we eat are one of the main areas which the group Flexible Systems investigates. We are also working to develop methods and pulse programs in Nuclear Magnetic Resonance (NMR) that allow us to uncover obscured metabolites and to detect them at lower concentrations, in order to understand metabolic pathways better. 


Why the name Flexible Systems?

It's simple; because metabolites, as well as amylin and its analogues, are very flexible systems i.e. amylin does not have a defined 3D structure, and in the case of the small molecules and metabolites we study, while they do have defined structures, they often exhibit very high levels of dynamic flexibility due to their size.

Untangling untidy folds to understand diseases

Copper ions could play a key role when peptide folding goes wrong and leads to harmful aggregates.

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Picking the best methods for metabolomics research

Comparison of different nuclear magnetic resonance spectroscopy methods has helped to identify the most robust approach for studying different types of biomolecules.

Latest Publications

Chapter 5 - Metabolic biomarkers in cancer

by Kacper Szczepski, Inas Al-Younis, Manel Dhahri, Joanna Izabela Lachowicz, Zeyad A. Al-Talla, Hanan Almahasheer, Noura Alasmael, Mahbuba Rahman, Abdul-Hamid Emwas, Lukasz Jaremko, Mariusz Jaremko
Book Chapter Year: 2023 DOI: https://doi.org/10.1016/B978-0-323-99924-3.00005-4

Abstract

Over the course of years healthcare systems have utilized various “-omics” approaches to prognose, diagnose, and evaluate the treatment efficacy of cancer diseases. Metabolomics is one of the latest prominent additions to the -omics approaches, characterized by its versatile methodology. Owing to constant improvements in the field, metabolomics aims to provide a faster and a more accurate diagnosis, as well as personalized and optimal strategies of treatment. In recent years, a growing number of studies have utilized metabolomics approach to find new disease-related biomarkers of cancer diseases. Here we present the summary of recent advances in biomarker discovery for various types of cancers such as leukemia, ovarian, lung, breast, and liver cancers as well as cancer-related cachexia.