The secrets of life lie in the molecular flexibility.

Welcome to Prof. Mariusz Jaremko's research group, the

Flexible Systems Lab!

Our research group works mainly on metabolites which are important for human health, and our current main focus in this discipline is oriented towards food, food safety, food quality, and food fraud by utilizing state-of-the-art instrumentation in metabolomics studies. We are also working on aggregation of amylin, a biological peptide that is connected tightly with diabetes II, a disease that is closely related to unhealthy diets. So, food science and the consequences of the food we eat are one of the main areas which the group Flexible Systems investigates. We are also working to develop methods and pulse programs in Nuclear Magnetic Resonance (NMR) that allow us to uncover obscured metabolites and to detect them at lower concentrations, in order to understand metabolic pathways better. 


Why the name Flexible Systems?

It's simple; because metabolites, as well as amylin and its analogues, are very flexible systems i.e. amylin does not have a defined 3D structure, and in the case of the small molecules and metabolites we study, while they do have defined structures, they often exhibit very high levels of dynamic flexibility due to their size.

Latest Publications

Metabolomics-based analysis of the diatom Cheatoceros tenuissimus combining NMR and GC–MS techniques
Original Article Year: 2024 DOI:https://doi.org/10.1016/j.mex.2024.102695
Authors: Afrah Alothman, Abdul-Hamid Emwas, Upendra Singh, Mariusz Jaremko, Susana Agusti
  • Metabolomics
Mitigating diabetes associated with reactive oxygen species (ROS) and protein aggregation through pharmacological interventions
Review Article Year: 2024 DOI:https://doi.org/10.1039/D4RA02349H
Authors: Giulia Bennici, Hanan Almahasheer, Mawadda Alghrably, Daniela Valensin, Arian Kola, Chrysoula Kokotidou, Joanna Izabela Lachowicz, Mariusz Jaremko
  • Aggregation
Metabolites from Marine Macroorganisms of the Red Sea Acting as Promoters or Inhibitors of Amylin Aggregation
Original Article Year: 2024 DOI:https://doi.org/10.3390/biom14080951
Authors: Mawadda Alghrably, Mohamed A. Tammam, Aikaterini Koutsaviti, Vassilios Roussis, Xabier Lopez, Giulia Bennici, Abeer Sharafalddin, Hanan Almahasheer, Carlos M. Duarte, Abdul-Hamid Emwas, Efstathia Ioannou, Mariusz Jaremko
  • Amylin
  • Aggregation
  • Natural products