Over the course of years healthcare systems have utilized various “-omics” approaches to prognose, diagnose, and evaluate the treatment efficacy of cancer diseases. Metabolomics is one of the latest prominent additions to the -omics approaches, characterized by its versatile methodology. Owing to constant improvements in the field, metabolomics aims to provide a faster and a more accurate diagnosis, as well as personalized and optimal strategies of treatment. In recent years, a growing number of studies have utilized metabolomics approach to find new disease-related biomarkers of cancer diseases. Here we present the summary of recent advances in biomarker discovery for various types of cancers such as leukemia, ovarian, lung, breast, and liver cancers as well as cancer-related cachexia.