My main field of expertise is the biomolecular NMR spectroscopy with the primary focus on molecular level description of functioning and detection of biologically relevant biomolecules and metabolites. My research interests can be divided into two main groups:

Detecting and revealing the function of proteins, metabolites, and natural products: I try to understand and describe the basic principles of protein folding and misfolding under as close as possible physiologically relevant conditions. Detailed knowledge about how proteins adopt their native, biologically essential for life structures and dynamics alongside with the knowledge what makes them to transform into the pathological forms, like amyloids, is the key question of the present-day biophysics. Studying the protein conformational landscape mystery is believed to allow the rational design of new drugs and efficient therapies against numerous diseases, like Alzheimer and Parkinson diseases, as well as other protein aggregation related diseases, like diabetes type II. In line with proteins, I study the metabolites from various samples, ranging from patient and environment using and further developing high-resolution state of the art techniques, NMR and MS. I am also working on isolation and identification of small molecular-weight natural products from environmental samples to discover novel chemistry to examine their biomedical and biotechnological potential for human and environment.

Biophysical/methodological interests: With high-resolution NMR I study the residual structure and folding of intrinsically disordered proteins, protein-protein interactions, relaxation, and molecular dynamics. Moreover, I also work on the NMR methodology development that would increase the accuracy, sensitivity and precision of the NMR measurements that will result in the detection of new metabolites and old metabolites at lower concentrations. The collaboration with SFDA and MEWA (Saudi Arabia) pushed me towards methods and metabolomics platform development. This type of techniques will be used for the improvement of food and health related research.

Five most recent publications:

• Singh, U., Al-Nemi, R., Alahmari, F., Emwas, A. H., & Jaremko, M. (2023). Improving quality of analysis by suppression of unwanted signals through band-selective excitation in NMR spectroscopy for metabolomics studies. Metabolomics, 20(1), 7.
• Thakral, S., Yadav, A., Kumar, M., Kumar, P., Narang, R., Sudhakar, K., Verma, A., Khalilullah, H., Jaremko, M., Emwas A.-H. (2023) Molecular aspects and treatment opportunities using herbal drugs, Ageing Res. Rev., 88, 101960 2).
• Abdelrahman, S., Ge, R., Samkari, F., Liu, Y., Susapto, H. H., Moretti, M., Liu, X., Hoehndorf, R., Emwas, A.-H., Jaremko, M., Hauser, C. A. E. (2023) The Impact of Mechanical Cues on the Metabolomic and Transcriptomic Profiles of Human Dermal Fibroblasts Cultured in Ultrashort SelfAssembling Peptide 3D Scaffolds, ACS Nano, 17, 15, 14508–14531; 3).
• Radwan, E. M., Abo-Elabass, E., Abd El-Baky, A. E., Alshwyeh, H., Almaimani, R. A., Almaimani, G., Ibrahim, I. A. A., Jaremko, M., Alshawwa, S. Z., Saied, E. M. (2023) Unveiling the Antitumor Potential of Novel N-(Substituted-Phenyl)-8-Methoxycoumarin-3-Carboxamides as Dual Inhibitors of VEGFR2 Kinase and Cytochrome P450 for Targeted Treatment of Hepatocellular Carcinoma, Front. Chem., 11, 1231030; 4).
• El-Atawy, M. A., Khan, M. T., Popoola, S. A., Khushaim, M. S., Jaremko, M., Emwas, A.-H., Alamro, F. S., Naoum, M. M., Ahmed, H. A. (2023) First mesomorphic and DFT characterizations for 3- (or 4-) n-alkanoyloxy benzoic acids and their optical applications, Heliyon, 9(9), e19384; 5).

Five most representative publications (for metabolomics studies):

• Almulhim, F., Rossbach, S., Emwas, A.-H., Kharbatia, N., Jaremko, L., Jaremko, M., Duarte, C. M. (2022) Metabolomic study on Tridacna maxima Giant Clams reveals metabolic fingerprint of environmental pollutants, Front. Mar. Sci., 9, 813404; 3).
• Emwas, A.-H., Szczepski, K., Poulson, B. G., Chandra, K., McKay, R. T., Dhahri, M., Alahmari, F., Jaremko, L., Lachowicz, J. I., Jaremko, M. (2020) NMR as a “Gold Standard” Method in Drug Design and Discovery. Molecules 25, 4597; 4).
• Chandra, K., Al-Harthi, S., Sukumaran, S., Almulhim, F., Emwas, A.-H., Atreya, H. S., Jaremko, Ł., Jaremko, M. (2021) NMR-based Metabolomics with Enhanced Sensitivity, RSC Advances, 11(15), 8694-8700; 5).
• Chandra, K., Al-Harthi, S., Almulhim, F., Emwas, A.-H., Jaremko, Ł., Jaremko, M. (2021) The robust NMR Toolbox for Metabolomics, Mol. Omics, 17, 719-724

• Ph.D. in Biophysics at the Institute of Biochemistry and Biophysics of Polish Academy of Sciences (PAS), Warsaw, Poland, 2008-2012.
• M.Sc. in Chemistry at the Wrocław University, Wrocław, Poland (supervisor Prof. Piotr Stefanowicz), 2008
• Interdisciplinary Individual Studies at the Wrocław University, Wroclaw, Poland (Departments of Chemistry, Physics), 2003-2008.

• 2017-present: Assistant Professor at the Biological and Environmental Science and Engineering (BESE) Division at King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
• 2016-2017: Independent Senior Postdoctoral Researcher with the Erwin Neher Nobel Fellowship at Max-Planck Institute for Biophysical Chemistry (Prof. Christian Griesinger Department).
• 2013-2015: Post-doctoral training at Max-Planck Institute for Biophysical Chemistry, Goettingen, Germany (Prof. Christian Griesinger Department).
• 2012 Dec 6th: Ph.D. summa cum laude, Institute of Biochemistry and Biophysics of Polish Academy of Sciences PAS, Poland (supervisor Prof. Andrzej Ejchart).

Young Investigator Award, ENC, 2016.

Erwin Neher Nobel Fellowship, 2015.

Finalist of the Galenus-von-Pergamon and Springer Medizin contest, 2014.

FGMR Ernst Award for the fundamental contribution to the NMR research field, 2013.

Division of Biological and Environmental Sciences and Engineering (BESE)

Red Sea Research Center (RSRC)

Smart-Health Initiative (SHI)